Publications
Books
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Magnetic Resonance Elastography: Physical Background And Medical Applications
Hirsch S, Braun J, Sack I
Wiley-VCH ISBN-10: 3527340084
From the cover:
Magnetic resonance elastography (MRE) is a medical imaging technique that combines magnetic resonance imaging (MRI) with mechanical vibrations to generate maps of viscoelastic properties of biological tissue. It serves as a non-invasive tool to detect and quantify mechanical changes in tissue structure, which can be
symptoms or causes of various diseases. Clinical and research applications of MRE include staging of liver fi brosis, assessment of tumor stiff ness and investigation of neurodegenerative diseases. The first part of this book is dedicated to the physical and technological principles underlying MRE, with an introduction to MRI physics,viscoelasticity theory and classical waves, as well as vibration generation, image acquisition and viscoelastic parameter reconstruction.The second part of the book focuses on clinical applications of MRE to various organs. Each section starts with a discussion of the specifi c properties of the organ, followed by an extensive overview of clinical and preclinical studies that have been performed, tabulating reference values from published literature. The book is completed by a chapter discussing technical aspects of elastography methods based on ultrasound.
From the content:
- NMR and MRI (from Bloch simulations to balanced SSFP-MRE)
- Motion encoding (from flow compensation to fractional encoding)
- Theory of elasticity (from generalized Hooke’s law to transverse isotropy)
- Viscoelasticity (from Kelvin-Voigt to fractal ladders)
- Elastic waves (from Green’s function to shear wave diffusion)
- Numerical tools (from phase unwrapping and compact gradient operators to wavelet denoising)
- Inversion methods (from Helmholtz inversion to waveguide elastography)
- MRE Hardware (scanners and actuators)
- Clinical background (the pathological cascade of liver fibrosis, biophysics of cancer, cardiac dysfunction and more)
- In vivo tissue properties (brain, liver, muscle, heart, spleen, kidney, pancreas, prostate, uterus, intervertebral disc)
- Ultrasound elastography methods (from ARFI to time harmonic elastography)
Quantification of Biophysical Parameters in Medical Imaging
Sack I, Schäffter T (Editors)
Springer, ISBN-10: 3319659235
Among the 25% most downloaded scientific e-books of Springer
From the cover:
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
This book reviews current state-of-the-art approaches and technologies in medical imaging. Most of the authors are associated to the Graduiertenkolleg GRK2260 BIOQIC (BIOphysical Quantitative Imaging towards Clinical diagnosis) which is currently funded by the German Research Foundation (DFG).
From the content:
| Chapter # | Chapter | Corresponding author name |
| 1 | Preface | Ingolf Sack |
| Part 1 | Biological and Physical Fundamentals | |
| 2 | The fundamentals of transport in living tissues quantified by medical imaging technologies | Ingolf Sack |
| 3 | Mathematical modeling of blood flow in the cardiovascular system | Alfonso Caiazzo |
| 4 | Equations of motion for biphasic tissue | Sebastian Hirsch |
| 5 | Physical Properties of Single Cells and Collective Behavior | Hans Kubitschke |
| 6 | The extracellular matrix as a target for molecular and biophysical magnetic resonance imaging | Matthias Taupitz |
| Part 2 | Medical Imaging Technologies | |
| 7 | Mathematical Methods in Medical Image Processing | Gitta Kutyniok |
| 8 | Acceleration strategies for data sampling in MRI | Christoph Kolbitsch |
| 9 | 4D flow MRI | Sebastian Schmitter |
| 10 | CEST MRI | Leif Schröder |
| 11 | Innovative PET and SPECT Tracers | Ulrich Abram |
| 12 | Methods and approaches in ultrasound elastography | Heiko Tzschätzsch |
| 13 | Photoacoustic imaging: Principles and Applications | Jan Laufer |
| 14 | Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction | Marc Dewey |
| Part 3 | Applications | |
| 15 | Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology | Thoralf Niendorf |
| 16 | Extracellular-matrix-specific molecular MR imaging probes for the assessment of aortic aneurysms | Marcus Makowski |
| 17 | Diffusion based MRI – imaging basics and clinical applications | Michael Scheel |
| 18 | Quantification of functional heterogeneities in tumors by PET imaging | Winfried Brenner |
| 19 | Tumor characterization by ultrasound elastography and contrast-enhanced ultrasound | Thomas Fischer |
| 20 | Sensitivity of tissue shear stiffness to pressure and perfusion in health and disease | Jing Guo |
| 21 | Radionuclide imaging of cerebral blood flow | Ralph Buchert |
| 22 | Cardiac perfusion MRI | Amedeo Chiribiri |
| 23 | Myocardial Perfusion Assessment by 3D and 4D Computed Tomography | Marc Dewey |
Review Articles
The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.
Bergs J, Morr AS, Silva RV, Infante-Duarte C, Sack I.
Advanced Science (Weinh). 2024
Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation
Meyer T, Castelein J, Schattenfroh J, Morr AS, Silva RV, Tzschätzsch H, Reiter R, Guo J, Sack I
Progress in Nuclear Magnetic Resonance Spectroscopy 2024
MR Elastography in Cancer
Guo J, Savic LJ, Hillebrandt KH, Sack I
Investigative Radiology 2023
Magnetic resonance elastography from fundamental soft-tissue mechanics to diagnostic imaging
Sack I.
Nature Reviews Physics 2022
Summary and overview of the first ISMRM workshop on magnetic resonance elastography, August 25-26, 2022, Berlin, Germany
Guo J, Marticorena Garcia S, Sack I.
Magn Reson Med. 2022
Application of Magnetic Resonance Imaging in Liver Biomechanics: A Systematic Review
Seyedpour SM, Nabati M, Lambers L, Nafisi S, Tautenhahn HM, Sack I, Reichenbach JR, Ricken T
Front. Phys. 2021
Molecular MR Imaging of Prostate Cancer
Kader A, Brangsch J, Kaufmann JO, Zhao J, Mangarova DB, Moeckel J, Adams LC, Sack I, Taupitz M, Hamm B, Makowski MR.
Biomedicines. 2020
Liver Magnetic Resonance Elastography: Clinical Use and Interpretation
Guo J, Sack I, Marticorena S
In: Liver Elastography by Sebastian Müller (Ed.) Springer 2020
Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model
Keller S, Chapiro J, Brangsch J, Reimann C, Collettini F, Sack I, Savic LJ, Hamm B, Goldberg SN, Makowski M.
J Magn Reson Imaging. 2019
Magnetic Resonance Elastography of the Heart
Elgeti T, Sack I
Curr Cardiovasc Imaging Rep 2014
Characterization of Focal Breast Lesions by Means of Elastography
Fischer T, Sack I, Thomas A
Fortschr Röntgenstr 2013
Magnetresonanzelastographie 2.0: Hochaufgelöste Bildgebung zur Bestimmung von Elastizität, Viskosität und Druck weicher Gewebe
Sack I
Deutsche Medizinische Wochenschrift 2013
Magnetresonanzelastographie der Leber
Sack I, Fischer T, Thomas A, Braun J
Radiologe 2012
Magnetresonanz-Elastographie
Sack I
Deutsche Medizinische Wochenschrift 2008
A selection of our work on time-harmonic elastography by ultrasound can be found on
https://www.thelastography.com/
Original Research Papers
2024
229 Multifrequency Magnetic Resonance Elastography Detects Small Abdominal Lymph Node Metastasis by High Stiffness.
Neelsen C, Elgeti T, Meyer T, Grittner U, Mödl L, Furth C, Geisel D, Hamm B, Sack I, Marticorena Garcia SR.
Invest Radiol. 2024
228 On the relationship between viscoelasticity and water diffusion in soft biological tissues.
Braun J, Bernarding J, Snellings J, Meyer T, Dantas de Moraes PA, Safraou Y, Wells RG, Guo J, Tzschätzsch H, Zappe A, Pagel K, Sauer IM, Hillebrandt KH, Sack I.
Acta Biomater. 2024
227 Sensitivity of magnetic resonance elastography to extracellular matrix and cell motility in human prostate cancer cell line-derived xenograft models.
Kader A, Snellings J, Adams LC, Gottheil P, Mangarova DB, Heyl JL, Kaufmann JO, Moeckel J, Brangsch J, Auer TA, Collettini F, Sauer F, Hamm B, Käs J, Sack I, Makowski MR, Braun J.
Biomater Adv. 2024
226 Viscoelastic parameters derived from multifrequency MR elastography for depicting hepatic fibrosis and inflammation in chronic viral hepatitis.
Wang Y, Zhou J, Lin H, Wang H, Sack I, Guo J, Yan F, Li R.
Insights Imaging. 2024
225 Explorative study using ultrasound time-harmonic elastography for stiffness-based quantification of skeletal muscle function.
Yang Y, Shahryari M, Meyer T, Marticorena Garcia SR, Görner S, Salimi Majd M, Guo J, Braun J, Sack I, Tzschätzsch H.
Z Med Phys. 2024
224 Three-Dimensional Multifrequency MR Elastography for Microvascular Invasion and Prognosis Assessment in Hepatocellular Carcinoma.
Liu G, Shen Z, Chong H, Zhou J, Zhang T, Wang Y, Ma D, Yang Y, Chen Y, Wang H, Sack I, Guo J, Li R, Yan F.
J Magn Reson Imaging. 2024
223 Cortical matrix remodeling as a hallmark of relapsing-remitting neuroinflammation in MR elastography and quantitative MRI
Silva R V, Morr A S, Herthum H, Koch S P, Mueller , Batzdorf C S, Bertalan G, Meyer T, Tzschätzsch H, Kühl A A, Boehm-Sturm P, Braun J, Scheel M, Paul F, Infante-Duarte C, Sack I
Acta Neuropathol. 2024
2023
222 Shear Wave Elastography for Assessing Liver Stiffness in HCV-Infected Kidney Transplant Recipients after Direct-Acting Antiviral Treatment: A Comparative Study with Magnetic Resonance Elastography.
Almutawakel S, Halleck F, Dürr M, Grittner U, Schrezenmeier E, Budde K, Althoff CE, Hamm B, Sack I, Fischer T, Marticorena Garcia SR.
J Clin Med. 2023
221 Effects of kidney perfusion on renal stiffness and tissue fluidity measured with tomoelastography in an MRI-compatible ex vivo model.
Castelein J, Pamplona C, Armstrong Junior R, Vidal Dos Santos M, Sack I, Dierckx R, Moers C, Borra R.
Front Bioeng Biotechnol. 2023
220 Rapid MR elastography of the liver for subsecond stiffness sampling.
Anders M, Meyer T, Warmuth C, Pfeuffer J, Tzschaetzsch H, Herthum H, Shahryari M, Degenhardt K, Wieben O, Schmitter S, Schulz-Menger J, Schaeffter T, Braun J, Sack I.
Magn Reson Med. 2023
219 Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.
Meyer T, Kreft B, Bergs J, Antes E, Anders MS, Wellge B, Braun J, Doyley M, Tzschätzsch H, Sack I.
Front Bioeng Biotechnol. 2023
218 Feasibility of in vivo magnetic resonance elastography of mesenteric adipose tissue in Crohn’s disease.
Jensen LJ, Loch FN, Kamphues C, Shahryari M, Marticorena Garcia SR, Siegmund B, Weidinger C, Kühl AA, Hamm B, Braun J, Sack I, Asbach P, Reiter R.
Quant Imaging Med Surg. 2023
217 Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.
Sauer F, Grosser S, Shahryari M, Hayn A, Guo J, Braun J, Briest S, Wolf B, Aktas B, Horn LC, Sack I, Käs JA.
Adv Sci (Weinh). 2023
216 The influence of static portal pressure on liver biophysical properties.
Safraou Y, Krehl K, Meyer T, Mehrgan S, Jordan JEL, Tzschätzsch H, Fischer T, Asbach P, Braun J, Sack I, Guo J.
Acta Biomater. 2023
215 Characterization of renal fibrosis in rats with chronic kidney disease by in vivo tomoelastography.
Krehl K, Hahndorf J, Stolzenburg N, Taupitz M, Braun J, Sack I, Schnorr J, Guo J.
NMR Biomed. 2023
214 Displacement and Pressure Reconstruction from Magnetic Resonance Elastography Images: Application to an In Silico Brain Model.
Galarce F, Tabelow K, Polzehl J, Panagiotis Papanikas C, Vavourakis V, Lilaj L, Sack I, Caiazzo A.
SIAM Journal on Imaging Sciences. 2023
213 Tomoelastography and Pancreatic Extracellular Volume Fraction Derived From MRI for Predicting Clinically Relevant Postoperative Pancreatic Fistula.
Zhu L, Sun Z, Dai M, Wu H, Wang X, Xu J, Xue H, Jin Z, Nickel MD, Guo J, Sack I.
J Magn Reson Imaging. 2023
212 Three-dimensional multifrequency magnetic resonance elastography improves preoperative assessment of proliferative hepatocellular carcinoma.
Liu G, Ma D, Wang H, Zhou J, Shen Z, Yang Y, Chen Y, Sack I, Guo J, Li R, Yan F.
Insights Imaging. 2023
211 Ex vivo magnetic resonance elastography of the small bowel in Crohn’s disease.
Loch FN, Kamphues C, Beyer K, Schineis C, Asbach P, Reiter R, Sack I, Braun J.
Quant Imaging Med Surg. 2023
210 Brain inflammation induces alterations in glycosaminoglycan metabolism and subsequent changes in CS-4S and hyaluronic acid.
Silva RV, Biskup K, Zabala-Jouvin JK, Batzdorf CS, Stellmach C, Morr AS, Sack I, Ludwig A, Blanchard V, Infante-Duarte C.
Int J Biol Macromol. 2023
209 On the relationship between metabolic capacities and in vivo viscoelastic properties of the liver
Shahryari M, Keller S, Meierhofer D, Wallach I, Safraou Y, Guo J, Marticorena Garcia SR, Braun J, Makowski MR, Sack I, Berndt N. Front Bioeng Biotechnol. 2023
2022
208 Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties.
Bertalan G, Becker J, Tzschätzsch H, Morr A, Herthum H, Shahryari M, Greenhalgh RD, Guo J, Schröder L, Alzheimer C, Budday S, Franze K, Braun J, Sack I.
J Mech Behav Biomed Mater. 2022
207 Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions
Herthum H, Hetzer S, Kreft B, Tzschätzsch H, Shahryari M, Meyer T, Görner S, Neubauer H, Guo J, Braun J, Sack I.
Front Bioeng Biotechnol. 2022
206 Reduced tumor stiffness quantified by tomoelastography as a predicative marker for glypican-3-positive hepatocellular carcinoma.
Wang Y, Guo J, Ma D, Zhou J, Yang Y, Chen Y, Wang H, Sack I, Li R, Yan F.
Front Oncol. 2022
205 The effect of smoking on quantification of aortic stiffness by ultrasound time-harmonic elastography.
Elgeti T, Fröhlich M, Wismayer KK, Tzschätzsch H, Hamm B, Sack I, Schaafs LA.
Scientific Reports 2022
204 Mechanical properties of murine hippocampal subregions investigated by atomic force microscopy and in vivo magnetic resonance elastography.
Morr AS, Nowicki M, Bertalan G, Vieira Silva R, Infante Duarte C, Koch SP, Boehm-Sturm P, Krügel U, Braun J, Steiner B, Käs JA, Fuhs T, Sack I.
Scientific Reports 2022
203 Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease
Berndt N, Hudert CA, Eckstein J, Loddenkemper C, Henning S, Bufler P, Meierhofer D, Sack I, Wiegand S, Wallach I, Holzhütter HG
International Journal of Molecular Sciences 2022
202 Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles
Golusda L, Kühl AA, Lehmann M, Dahlke K, Mueller S, Boehm-Sturm P, Saatz J, Traub H, Schnorr J, Freise C, Taupitz M, Biskup K, Blanchard V, Klein O, Sack I, Siegmund B, Paclik D.
Front Physiol. 2022
201 Solid fraction determines stiffness and viscosity in decellularized pancreatic tissues
Snellings J, Keshi E, Tang P, Daneshgar A, Willma EC, Haderer L, Klein O, Krenzien F, Malinka T, Asbach P, Pratschke J, Sauer IM, Braun J, Sack I*, Hillebrandt K*.
Biomaterial Advances 2022
200 Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens
Abuhattum S, Kotzbeck P, Schlüßler R, Harger A, Ariza de Schellenberger A, Kim K, Escolano JC, Müller T, Braun J, Wabitsch M, Tschöp M, Sack I, Brankatschk M, Guck J, Stemmer K, Taubenberger AV.
Scientific Reports 2022
199 Valsalva Maneuver Decreases Liver and Spleen Stiffness Measured by Time-Harmonic Ultrasound Elastography
Meyer T, Tzschätzsch H, Wellge B, Sack I, Kröncke T, Martl A.
Front Bioeng Biotechnol. 2022
198 Comparison of inversion methods in MR elastography: An open-access pipeline for processing multifrequency shear-wave data and demonstration in a phantom, human kidneys, and brain
Meyer T, Marticorena Garcia S, Tzschätzsch H, Herthum H, Shahryari M, Stencel L, Braun J, Kalra P, Kolipaka A, Sack I.
Magn Reson Med. 2022
197 Added Value of Viscoelasticity for MRI-Based Prediction of Ki-67 Expression of Hepatocellular Carcinoma Using a Deep Learning Combined Radiomics (DLCR) Model
Hu X, Zhou J, Li Y, Wang Y, Guo J, Sack I, Chen W, Yan F, Li R, Wang C.
Cancers (Basel). 2022
196 Tomoelastography based on multifrequency MR elastography predicts liver function reserve in patients with hepatocellular carcinoma: a prospective study
Lin H, Wang Y, Zhou J, Yang Y, Xu X, Ma D, Chen Y, Yang C, Sack I, Guo J, Li R, Yan F.
Insights Imaging. 2022
195 Different Impact of Gadopentetate and Gadobutrol on Inflammation-Promoted Retention and Toxicity of Gadolinium Within the Mouse Brain
Anderhalten L, Silva RV, Morr A, Wang S, Smorodchenko A, Saatz J, Traub H, Mueller S, Boehm-Sturm P, Rodriguez-Sillke Y, Kunkel D, Hahndorf J, Paul F, Taupitz M, Sack I, Infante-Duarte C.
Invest Radiol. 2022
194 Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging
Herthum H, Carrillo H, Osses A, Uribe S, Sack I, Bertoglio C.
Medical Image Analysis 2022
*****Winner of the MDPI Biology 2024 Best Paper Award:
193 Sexual Dimorphism in Extracellular Matrix Composition and Viscoelasticity of the Healthy and Inflamed Mouse Brain
Biology 2022
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192 Liquid-Liver Phantom: Mimicking the Viscoelastic Dispersion of Human Liver for Ultrasound- and MRI-Based Elastography
Morr AS, Herthum H, Schrank F, Görner S, Anders MS, Lerchbaumer M, Müller HP, Fischer T, Jenderka KV, Hansen HHG, Janmey PA, Braun J, Sack I, Tzschätzsch H.
Investigative Radiology 2022
191 Fully automated quantification of in vivo viscoelasticity of prostate zones using magnetic resonance elastography with Dense U-net segmentation
Aldoj N, Biavati F, Dewey M, Hennemuth A, Asbach P, Sack I.
Scientific Reports 2022
2021
190 Microscopic multifrequency magnetic resonance elastography of ex vivo abdominal aortic aneurysms for extracellular matrix imaging in a mouse model
Mangarova DB, Bertalan G, Jordan J, Brangsch J, Kader A, Möckel J, Adams LC, Sack I, Taupitz M, Hamm B, Makowski MR, Braun J.
Acta Biomater. 2021
189 Whole tissue and single cell mechanics are correlated in human brain tumors
Sauer F, Fritsch A, Grosser S, Pawlizak S, Kießling T, Reiss-Zimmermann M, Shahryari M, Müller WC, Hoffmann KT, Käs JA, Sack I.
Soft Matter 2021
188 In vivo stiffness of multiple sclerosis lesions is similar to that of normal-appearing white matter.
Herthum H, Hetzer S, Scheel M, Shahryari M, Braun J, Paul F, Sack I.
Acta Biomater. 2021
This paper was awarded with the The QUEST 1,000 € NULL Results And Replication Study Award
187 Microscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish.
Jordan JEL, Bertalan G, Meyer T, Tzschätzsch H, Gauert A, Bramè L, Herthum H, Safraou Y, Schröder L, Braun J, Hagemann AIH, Sack I.
Magn Reson Med. 2021
186 Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging.
Möckel J, Brangsch J, Reimann C, Kaufmann JO, Sack I, Mangarova DB, Kader A, Taupitz M, Adams LC, Keller S, Ludwig A, Hamm B, Botnar RM, Makowski MR.
Biology (Basel). 2021
185 Added Value of Tomoelastography for Characterization of Pancreatic Neuroendocrine Tumor Aggressiveness Based on Stiffness.
Gültekin E, Wetz C, Braun J, Geisel D, Furth C, Hamm B, Sack I, Marticorena Garcia SR.
Cancers (Basel). 2021
184 Multifrequency magnetic resonance elastography-based tomoelastography of the parotid glands-feasibility and reference values.
Elsholtz FHJ, Reiter R, Marticorena Garcia SR, Braun J, Sack I, Hamm B, Schaafs LA.
Dentomaxillofac Radiol. 2021
183 Simulating Local Deformations in the Human Cortex Due to Blood Flow-Induced Changes in Mechanical Tissue Properties: Impact on Functional Magnetic Resonance Imaging
Zoraghi M, Scherf N, Jaeger C, Sack I, Hirsch S, Hetzer S, Weiskopf N
Front. Neurol. 2021
182 Contribution of Tissue Inflammation and Blood-Brain Barrier Disruption to Brain Softening in a Mouse Model of Multiple Sclerosis
Vieira Silva R, Morr AS, Mueller S, Koch SP, Boehm-Sturm P, Rodriguez-Sillke Y, Kunkel D, Tzschätzsch H, Kühl AA, Schnorr J, Taupitz M, Sack I and Infante-Duarte C
Front. Neurol. 2021
181 Rectal Tumor Stiffness Quantified by In Vivo Tomoelastography and Collagen Content Estimated by Histopathology Predict Tumor Aggressiveness.
Hu J, Guo J, Pei Y, Hu P, Li M, Sack I, Li W.
Front Oncol. 2021
180 Effect of post-mortem interval and perfusion on the biophysical properties of ex vivo liver tissue investigated longitudinally by MRE and DWI
Garczyńska K, Tzschätzsch H, Assili S, Kühl AA, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J
Front. Phys. 2021
179 Non-invasive detection of intracranial hypertension by novel ultrasound time-harmonic elastography
Kreft B, Tzschätzsch H, Shahryari M, Haffner P, Braun J, Sack I, Streitberger KJ
Invest. Radiol. 2021
178 Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease
Reiter R, Loch F, Kamphues C, Bayerl C, Marticorena S, Siegmund B, Kuehl A, Hamm B, Braun J, Sack I, Asbach P
J. Magn. Reson. Imag. 2021
177 Influence of fibrosis progression on the viscous properties of in vivo liver tissue elucidated by shear wave dispersion in multifrequency MR elastography
Reiter R, Shahryari M, Tzschätzsch H, Hass M, Bayerl C, Siegmund B, Hamm B, Asbach P, Braun J, Sack, I
J. Mechan. Behav. Biomed. Mat. 2021
176 Inversion recovery MR elastography of the human brain for improved stiffness quantification near fluid-solid boundaries.
Lilaj L, Herthum H, Meyer T, Shahryari M, Bertalan G, Caiazzo A, Braun J, Fischer T, Hirsch S, Sack I
Magn. Reson. Med. 2021
175 Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography.
Reiter R, Shahryari M, Tzschätzsch H, Klatt D, Siegmund B, Hamm B, Braun J, Sack I, Asbach P.
Sci Rep. 2021
174 Real-time multifrequency MR elastography of the human brain reveals rapid changes in viscoelasticity in response to the Valsalva maneuver
Herthum H, Shahryari M, Tzschätzsch H, Schrank F, Warmuth C, Görner S, Hetzer S, Neubauer H, Pfeuffer J, Braun J, Sack I
Front. Bioeng. Biotechnol. 2021
173 Real-time deformability cytometry detects leukocyte stiffening after gadolinium-based contrast agent exposure
Jacobi A, Ariza de Schellenberger A, Herbig M, Uca YO, Guck J, Sack I
Invest. Radiol. 2021
172 Tomoelastography Based on Multifrequency MR Elastography for Prostate Cancer Detection: Comparison with Multiparametric MRI
Li M, Guo J, Hu P, Jiang H, Chen J, Hu J, Asbach P, Sack I, Li W.
Radiology. 2021
171 Tomoelastography for Longitudinal Monitoring of Viscoelasticity Changes in the Liver and in Renal Allografts after Direct-Acting Antiviral Treatment in 15 Kidney Transplant Recipients with Chronic HCV Infection.
Marticorena Garcia SR, Althoff CE, Dürr M, Halleck F, Budde K, Grittner U, Burkhardt C, Jöhrens K, Braun J, Fischer T, Hamm B, Sack I, Guo J.
J. Clin. Med. 2021
170. Cerebral Ultrasound Time-Harmonic Elastography Reveals Softening of the Human Brain Due to Dehydration
Kreft B, Bergs J, Shahryari M, Danyel LA, Hetzer S, Braun J, Sack I and Tzschätzsch H
Frontiers in Phys. 2021
169. How histopathologic changes in pediatric nonalcoholic fatty liver diseases influence in vivo liver stiffness
Hudert CA, Tzschätzsch H, Rudolph B, Loddenkemper C, Holzhütter HG, Kalveram L, Wiegan S, Braun J, Sack I, Guo J.
Acta Biomater. 2021
2020
168. Superviscous properties of the in vivo brain at large scales
Hertum H, SCH Dempsey, Samani A, Schrank F, Shahryari M, Warmuth C, Tzschätzsch H, Braun J, Sack I
Acta Biomaterialia 2020
167. Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy
Garczyńska K, Tzschätzsch H, Kühl AA, Morr AS, Lilaj L, Häckel A, Schellenberger E, Berndt N, Holzhütter HG, Braun J, Sack I, Guo J
Front. Physiol. 2020
166. MR elastography: Principles, guidelines, and terminology.
Manduca A, Bayly PJ, Ehman RL, Kolipaka A, Royston TJ, Sack I, Sinkus R, Van Beers BE.
Magn Reson Med. 2020
165. Distinguishing pancreatic cancer and autoimmune pancreatitis with in vivo tomoelastography.
Zhu L, Guo J, Jin Z, Xue H, Dai M, Zhang W, Sun Z, Xu J, Marticorena Garcia SR, Asbach P, Hamm B, Sack I.
Eur Radiol. 2020
164. Reduction of breathing artifacts in multifrequency magnetic resonance elastography of the abdomen.
Shahryari M, Meyer T, Warmuth C, Herthum H, Bertalan G, Tzschätzsch H, Stencel L, Lukas S, Lilaj L, Braun J, Sack I.
Magn Reson Med. 2020
163. In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles.
Mohtashamdolatshahi A, Kratz H, Kosch O, Hauptmann R, Stolzenburg N, Wiekhorst F, Sack I, Hamm B, Taupitz M, Schnorr J.
Sci Rep. 2020
162. A stacked frequency approach for inhomogeneous time-dependent MRE: an inverse problem for the elastic shear modulus
Davies PJ, Sack I
SIAM Journal of Applied Mathematics 2020
161. Tomoelastography for non-invasive detection of ameloblastoma and metastatic neck lymph nodes.
Beier M, Sack I, Beck-Broichsitter B, Hamm B, Marticorena Garcia SR
BMJ Case Rep. 2020
160. Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography.
Lilaj L, Fischer T, Guo J, Braun J, Sack I, Hirsch S
Magn Reson Med. 2020
159. Tomoelastography for measurement of tumor volume related to tissue stiffness in pancreatic ductal adenocarcinomas.
Marticorena SG, Zhu L, Schmuck R, Gültekin E, Burkhardt C, Bahra M, Geisel D, Shahryari M, Braun J, Hamm B, Sack I, Guo J
Invest Radiol. 2020
158. In vivo quantification of water diffusion, stiffness, and tissue fluidity in benign prostatic hyperplasia and prostate cancer
Asbach P, Ro S, Aldoj N, Snellings J, Reiter R, Lenk J, Köhlitz T, Haas M, Guo J, Hamm B, Braun J, Sack I
Invest Radiol. 2020
157. An analytical solution to the dispersion-by-inversion problem in magnetic resonance elastography.
Mura J, Schrank F, Sack I.
Magn Reson Med. 2020
156. Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta – Validation and Reference Values
Schaafs LA, Schrank F, Warmuth C, Steffen IC, Braun J, Hamm B, Sack I, Elgeti T.
Invest Radiol. 2020 in print
155. Magnetic resonance elastography quantification of the solid-to-fluid transition of liver tissue due to decellularization
Everwien H, Ariza de Schellenberger A, Haep N, Tzschätzsch H, Pratschke J, Sauer IM, Braun J, Hillebrandt KH, Sack I
J Mech Behav Biomed Mat 2020
154. Time-Resolved Response of Cerebral Stiffness to Hypercapnia in Humans
Kreft B, Tzschätzsch H, Schrank F, Bergs J, Streitberger KJ, Wäldchen S, Hetzer S, Braun J, Sack I
Ultrasound Med Biol 2020
153. MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated With Clinical Severity in a Model of Multiple Sclerosis
Wang S, Millward JM, Hanke-Vela L, Malla B, Plich K, Gil-Infante A, Waiczies S, Mueller S, Boehm-Sturm P, Guo J, Sack I, Infante-Duarte C
Frontiers in Neurology 2020
152. Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility.
Burkhardt C, Tzschätzsch H, Schmuck R, Bahra M, Jürgensen C, Pelzer U, Hamm B, Braun J, Sack I, Marticorena Garcia SR.
Invest Radiol. 2020
151. Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.
Schaafs LA, Tzschätzsch H, Steffen IG, Braun J, Hamm B, Sack I, Elgeti T.
Invest Radiol. 2019 Dec 30
2019
150. How tissue fluidity influences brain tumor progression.
Streitberger KJ, Lilaj L, Schrank F, Braun J, Hoffmann KT, Reiss-Zimmermann M, Käs JA, Sack I.
Proc Natl Acad Sci U S A. 2019
149. Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises.
Schrank F, Warmuth C, Görner S, Meyer T, Tzschätzsch H, Guo J, Uca YO, Elgeti T, Braun J, Sack I.
Magn Reson Med. 2019
148. Biomechanical properties of the hypoxic and dying brain quantified by magnetic resonance elastography.
Bertalan G, Klein C, Schreyer S, Steiner B, Kreft B, Tzschätzsch H, de Schellenberger AA, Nieminen-Kelhä M, Braun J, Guo J, Sack I.
Acta Biomater. 2019
147. Diagnostic performance of tomoelastography of the liver and spleen for staging hepatic fibrosis.
Reiter R, Tzschätzsch H, Schwahofer F, Haas M, Bayerl C, Muche M, Klatt D, Majumdar S, Uyanik M, Hamm B, Braun J, Sack I, Asbach P.
Eur Radiol. 2019
146. Tomoelastography distinguishes non-invasively between benign and malignant liver lesions.
Shahryari M, Tzschätzsch H, Guo J, Marticorena Garcia SR, Böning G, Fehrenbach U, Stencel L, Asbach P, Hamm B, Käs JA, Braun J, Denecke T, Sack I.
Cancer Research 2019
145. Viscoelasticity of striatal brain areas reflects variations in body mass index of lean to overweight male adults.
Hetzer S, Hirsch S, Braun J, Sack I, Weygandt M.
Brain Imaging and Behavior 2019
144. Tomoelastography for non-invasive detection and treatment monitoring in acute appendicitis.
Marticorena Garcia SR, Hamm B, Sack I.
BMJ Case Rep. 2019
143. Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity.
Guo J, Bertalan G, Meierhofer D, Klein C, Schreyer S, Steiner B, Wang S, Vieira da Silva R, Infante-Duarte C, Koch S, Boehm-Sturm P, Braun J, Sack I.
Acta Biomater. 2019
142. Ultrasound Time-Harmonic Elastography of the Aorta: Effect of Age and Hypertension on Aortic Stiffness.
Schaafs LA, Tzschätzsch H, Reshetnik A, van der Giet M, Braun J, Hamm B, Sack I, Elgeti T.
Invest. Radiol. 2019
141. The MRE Inverse Problem for the Elastic Shear Modulus
Davies PJ, Barnhill E, Sack I
SIAM J. Appl. Math., 79(4), 1367–1388.
140. US Time-Harmonic Elastography for the Early Detection of Glomerulonephritis.
Grossmann M, Tzschätzsch H, Lang ST, Guo J, Bruns A, Dürr M, Hoyer BF, Grittner U, Lerchbaumer M, Nguyen Trong M, Schultz M, Hamm B, Braun J, Sack I, Marticorena Garcia SR.
Radiology 2019
139. Multiparametric Quantitative MRI for the Detection of IgA Nephropathy Using Tomoelastography, DWI, and BOLD Imaging.
Lang ST, Guo J, Bruns A, Dürr M, Braun J, Hamm B, Sack I, Marticorena Garcia SR.
Invest. Radiol. 2019
138. The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain.
Bertalan G, Boehm-Sturm P, Schreyer S, Morr AS, Steiner B, Tzschätzsch H, Braun J, Guo J, Sack I.
Acta Biomater. 2019
137. Quantitative Time-Harmonic Ultrasound Elastography of the Abdominal Aorta and Inferior Vena Cava.
Schaafs LA, Tzschätzsch H, Figiel C, van der Giet M, Reshetnik A, Hamm B, Sack I, Elgeti T.
Ultrasound Med. Biol. 2019
136. Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.
Schrank F, Warmuth C, Tzschätzsch H, Kreft B, Hirsch S, Braun J, Elgeti T, Sack I.
J.Cereb.Blood Flow Metab. 2019
135. Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine: A Proof-of-Concept Study in Mice Combining ICP-MS and Micro- and Nano-SR-XRF.
Wang S, Hesse B, Roman M, Stier D, Castillo-Michel H, Cotte M, Suuronen JP, Lagrange A, Radbruch H, Paul F, Taupitz M, Schellenberger E, Sack I, Infante-Duarte C.
Invest. Radiol. 2019
134. Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue.
de Schellenberger AA, Tzschätzsch H, Polchlopek B, Bertalan G, Schrank F, Garczynska K, Janmey PA, Braun J, Sack I.
J Biomech. 2019
133. Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent.
Sauer F, Oswald L, Ariza de Schellenberger A, Tzschätzsch H, Schrank F, Fischer T, Braun J, Mierke CT, Valiullin R, Sack I, Käs JA.
Soft Matter. 2019
132. Non-invasive structure-function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test.
Heucke N, Wuensch T, Mohr J, Kaffarnik M, Arsenic R, Sinn B, Müller T, Pratschke J, Stockmann M, Sack I, Tzschätzsch H.
J Gastroenterol Hepatol. 2019
131. A prospective study of daclatasvir and sofosbuvir in chronic HCV-infected kidney transplant recipients.
Duerr M, Schrezenmeier EV, Lehner LJ, Bergfeld L, Glander P, Marticorena Garcia SR, Althoff CE, Sack I, Brakemeier S, Eckardt KU, Budde K, Halleck F.
BMC Nephrol 2019
130. Fast robust dejitter and interslice discontinuity removal in MRI phase acquisitions: application to magnetic resonance elastography
Barnhill E., Nikolova M, Ariyurek C, Dittmann F, Braun J, Sack I
IEEE Transactions on Medical Imaging 2019
2018
129. In vivo time-harmonic ultrasound elastography of the human brain detects acute cerebral stiffness changes induced by intracranial pressure variations
Tzschätzsch H, Kreft B, Schrank F, Bergs J, Braun J, Sack I
Scientific Reports 2018
128. Fast tomoelastography of the mouse brain by multifrequency single-shot MR elastography
Bertalan G, Guo J, Tzschätzsch H, Klein C, Barnhill E, Sack I, Braun J
Magnetic Resonance in Medicine 2018
127. Tomoelastography for the evaluation of pediatric non-alcoholic fatty liver disease
Hudert C, Tzschätzsch H, Rudolph B, Bläker H, Loddenkemper C, Müller H-P, Henning S, Bufler P, Hamm B, Braun J, Holzhütter HG, Wiegand S, Sack I, Guo J
Investigative Radiology 2018
126. Tomoelastography paired with T2* magnetic resonance imaging detects lupus nephritis with normal renal function
Marticorena Garcia SR, Grossmann M, Bruns A, Dürr M, Tzschätzsch H, Hamm B, Braun J, Sack I, Guo J
Investigative Radiology 2018
125. Hypercapnia increases brain viscoelasticity
Hetzer S, Dittmann F, Bormann K, Hirsch S, Lipp A, Wang DJJ, Braun J, Sack I
Journal of Cerebral Blood Flow and Metabolism 2018
124. Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE).
Reiter R, Wetzel M, Hamesch K, Strnad P, Asbach P, Haas M, Siegmund B, Trautwein C, Hamm B, Klatt D, Braun J, Sack I, Tzschätzsch H.
PLoS One 2018
123. Heterogeneous Multifrequency Direct Inversion (HMDI) for magnetic resonance elastography with application to a clinical brain exam
Barnhill E, Davis PJ, Ariyurek C, Fehlner A, Braun J, Sack I
Medical Image Analysis 2018
122. Ultrasound time-harmonic elastography: detection of liver fibrosis in extremely obese adolescents with non-alcoholic fatty liver disease
Hudert C, Tzschätzsch H, Guo J, Rudolph B, Bläker H, Loddenkemper C, Luck W, Müller H-P, Baumgart DC, Hamm B, Braun J, Holzhütter HG, Wiegand S, Sack I
Radiology 2018
121. Full-field-of-view time harmonic elastography of the native kidney
Marticorena Garcia SR, Großmann M, Lang ST, Nguyen Trong M, Schultz M, Guo J, Hamm B, Braun J, Sack I, Tzschätzsch H
Ultrasound in Medicine and Biology 2018
120. Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer’s disease based on Magnetic resonance imaging
Gerischer LM, Fehlner A, Koebe T, Prehn K, Antonenko D, Grittner U, Braun J, Sack I, Flöel A
Neuroimage: Clinical 2018
2017
119. Progressive Supranuclear Palsy and idiopathic Parkinson’s disease are associated with local reduction of in-vivo brain viscoelasticity
Lipp A, Skowronek C, Fehlner A, Streitberger K-J, Braun J, Sack I
Europ. Radiol. 2017
118. Comparison of Ultrasound Shear Wave Elastography with Magnetic Resonance Elastography and Renal Microvascular Flow in the Assessment of Chronic Renal Allograft Dysfunction
Marticorena Garcia SR, Guo J, Dürr M, Denecke T, Hamm B, Sack I, Fischer T
Acta Radiologica 2017
117. Tomoelastography of the native kidney: Regional variation and physiological effects on in vivo renal stiffness.
Marticorena Garcia SR, Grossmann M, Lang ST, Tzschätzsch H, Dittmann F, Hamm B, Braun J, Guo J, Sack I
Magnetic Resonance in Medicine 2017
116. Time-harmonic ultrasound elastography of the descending abdominal aorta: initial results.
Schaafs LA, Tzschätzsch H, van der Giet M, Reshetnik A, Steffen IG, Hamm B, Braun J, Sack I, Elgeti T
Ultrasound in Medicine and Biology 2017
115. Viscoelastic power law parameters of in vivo human brain estimated by MR elastography.
Testu J, McGarry MDJ, Dittmann F, Weaver JB, Paulsen KD, Sack I, Van Houten EEW
J Mech Behav Biomed Mater 2017
114. Tomoelastography of the prostate using multifrequency MR elastography and externally placed pressurized-air drivers.
Dittmann F, Reiter R, Guo J, Haas M, Asbach P, Fischer T, Braun J, Sack I
Magnetic Resonance in Medicine 2017
113. MR elastography detection of early viscoelastic response of the murine hippocampus to amyloid β accumulation and neuronal cell loss due to Alzheimer’s disease.
Munder T, Pfeffer A, Schreyer S, Guo J, Braun J, Sack I, Steiner B, Klein C
Jounral of Magnetic Resonance Imaging 2017
112. A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation.
Braun J, Tzschätzsch H, Körting C, Ariza de Schellenberger A, Jenderka M, Drießle T, Ledwig M, Sack I
Magnetic Resonance in Medicine 2017
111. Physiological reduction of hepatic venous blood flow by Valsalva maneuver decreases liver stiffness.
Ipek-Ugay S, Tzschätzsch H, Fischer T, Braun J, Sack I
Journal of Ultrasound in Medicine 2017
110. Perfusion alters stiffness of deep gray matter.
Hetzer S, Birr P, Fehlner A, Hirsch S, Dittmann F, Barnhill E, Braun J, Sack I
Journal of Cerebral Blood Flow and Metabolism 2017
109. Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans.
Berndt D, Millward JM, Schnorr J, Taupitz M, Stangl V, Paul F, Wagner S, Wuerfel JT, Sack I, Ludwig A, Infante-Duarte C
Nanomedicine 2017
2016
108. Magnetic Resonance Elastography through Atherosclerosis: A Feasibility Study.
Thomas-Seale LEJ, Kennedy P, Hollis L, Hammer S, Anderson T, Mirsadraee S, Klatt D, Sack I, Pankaj P, Roberts N and Hoskins PR
Journal of Clinical & Experimental Cardiology 2016
107. Time-harmonic elastography of the liver is sensitive to intrahepatic pressure gradient and liver decompression following transjugular intrahepatic portosystemic shunt (TIPS) implantation.
Tzschätzsch H, Sack I, Marticorena-Garcia SR, Ipek-Ugay S, Braun J, Hamm B, Althoff CE
Ultrasound in Medicine and Biology 2016
106. Increasing the Spatial Resolution and Sensitivity of Magnetic Resonance Elastography by Correcting for Subject Motion and Susceptibility-induced Image Distortions.
Fehlner A, Hirsch H, Weygandt M, Christophel T, Barnhill E, Kadobianskyi M, Lützkendorf R, Braun J, Bernarding J, Sack I, Hetzer S
Journal of Magnetic Resonance Imaging 2016
105. Tomoelastography of the abdomen: Tissue mechanical properties of the liver, spleen, kidney and pancreas from single MR elastography scans at different hydration states.
Dittmann F, Tzschätzsch H, Hirsch S, Barnhill E, Braun J, Sack I, Guo J
Magnetic Resonance in Medicine 2016
104. Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder.
Streitberger K-J, Fehlner A, Pache F, Lacheta A, Papazoglou S, Bellmann-Strobl J, Ruprecht K, Brandt A, Braun J, Sack I, Paul F, Wuerfel J
European Radiology 2016
103. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue
Hain EG, Klein C, Munder T, Braun J, Riek K, Mueller S, Sack I, Steiner B
Plos One 2016
102. Two-dimensional time-harmonic elastography of the human liver and spleen
Tzschätzsch H.,Trong M., Scheuermann T., Ipek-Ugay S., Fischer T., Schultz M., Braun J., Sack I.
Ultrasound in Medicine and Biology 2016
101. Nonlinear Multiscale Regularisation in MR Elastography: Towards Fine Feature Mapping
Barnhill E, Hollis L, Sack I, Braun J, Hoskins PR, Pankaj P, Brown C, van Beek EJR, Roberts N
Medical Image Analysis 2016
100. The simulation of magnetic resonance elastography through atherosclerosis.
Thomas-Seale LE, Hollis L, Klatt D, Sack I, Roberts N, Pankaj P, Hoskins PR.
Journal of Biomechanics 2016
99. Multifrequency Magnetic Resonance Elastography for the Assessment of Renal Allograft Function
Marticorena S., Fischer T., Dürr M., Gültekin E., Braun J., Sack I., Guo J.
Investigative Radiology 2016
98. Time harmonic elastography reveals sensitivity of liver stiffness to water ingestion
Ipek-Ugay S., Tzschätzsch H., Hudert C., Garcia S.R.M., Fischer T., Braun J., Althoff C. and Sack I.
Ultrasound in Medicine and Biology 2016
97. Tomoelastography by multifrequency wave number recovery from time-harmonic propagating shear waves
Tzschätzsch H., Guo J., Dittmann F., Hirsch S. , Barnhill E., Jöhrens K., Braun J. and Sack I.
Medical Image Analysis 2016
2015
96. Higher-Resolution MR Elastography Reveals Early Mechanical Signatures of Neuroinflammation in Patients with Clinically Isolated Syndrome
Fehlner A., Behrens J.R., Streitberger K.-J., Papazoglou S., Braun J., Bellmann-Strobl J., Ruprecht K., Paul F., Wuerfel J. and Sack I.
Journal of Magnetic Resonance Imaging 2015
(the cover shows elastograms and parameter difference maps for the disease CIS, which is a very early stage of MS)
95. In Vivo Wideband Multifrequency MR Elastography of the Human Brain and Liver
Dittmann F., Hirsch S., Tzschätzsch H., Guo J., Braun J. and Sack I.
Magnetic Resonance in Medicine 2015
94. Cerebral multifrequency MR elastography by remote excitation of intracranial shear waves
Fehlner A., Papazoglou S., McGarry M.D., Paulsen K.D., Guo J., Streitberger K.-J., Hirsch S., Braun J. and Sack I.
NMR in Biomedicine 2015
93. Time-Resolved Analysis of Left Ventricular Shear Wave Amplitudes in Cardiac Elastography for the Diagnosis of Diastolic Dysfunction
Elgeti T., Steffen I.G., Knebel F., Hättasch R., Hamm B., Braun J. and Sack I.
Investigative Radiology 2016
92. Three-Parameter Shear Wave Inversion in MR Elastography of Incompressible Transverse Isotropic Media: Application to In Vivo Lower Leg Muscles
Guo J., Hirsch S., Scheel M., Braun J. and Sack I.
Magnetic Resonance in Medicine 2015
91. Tissue structure and inflammatory processes shape viscoelastic properties of the mouse brain
Millward J.M., Guo J., Dominique Berndt D., Braun J., Sack I. and Infante-Duarte C.
NMR in Biomedicine 2015
90. In Vivo Abdominal Magnetic Resonance Elastography for the Assessment of Protal Hypertension Before and After Transjugular Intrahepatic Portosystemic Shunt Implantation
Guo J., Büning C., Schott E., Kröncke T., Braun J., Sack I., Althoff C.
Investigative Radiology 2015
89. US-based Real-time Elastography for the Detection of Fibrotic Gut Tissue in Patients with Stricturing Crohn Disease
Baumgart DC., Müller HP., Grittner U., Metzke D., Fischer A., Guckelberger O., Pascher A., Sack I., Vieth M., Rudolph B.
Radiology 2015
88. Multifrequency time-harmonic elastography for the measurement of liver viscoelasticity in large tissue windows
Tzschätzsch H., Ipek-Ugay S., Trong M., Guo J., Eggers J., Gentz E., Fischer T.,Schultz M., Braun J., Sack I.
Ultrasound in Medicine and Biology 2015
2014
87. Tabletop Magnetic Resonance Elastography for the Measurement of Viscoelastic Parameters of Small Tissue Samples
Ipek-Ugay S., Drießle T., Ledwig M., Guo J., Hirsch S., Sack I., Braun J.
Journal of Magnetic Resonance 2015
86. In vivo multifrequency magnetic resonance elastography of the human intervertebral disk
Streitberger J., Diederichs G., Guo J., Fehlner A., Hamm B., Braun J., Sack I.
Magnetic Resonance in Medicine 2014
85. High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography
Streitberger J., Reiss-Zimmermann M., Freimann F.B., Bayerl S., Guo J., Arlt F., Wuerfel J., Braun J., Hoffmann K.-T., Sack I.
PlosOne 2014
84. In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix
Jiang X., Asbach P., Streitberger J., Thomas A., Hamm B., Braun J., Sack I., Guo J.
European Radiology 2014
83. High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography
Reiss-Zimmermann M., Streitberger J., Sack I., Braun J., Arlt F., Fritzsch D., Hoffmann K.-T.
Clin Neuroradiol 2014
82. Wideband MRE and static mechanical indentation of human liver specimen: Sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis
Reiter R., Freise C., Jöhrens K., Kamphues C., Seehofer D., Stockmann M., Somasundarame R., Asbach P., Braun J., Samani A., Sack I.
Journal of Biomechanics 2014
81. Enhanced Adult Neurogenesis Increases Brain Stiffness: In Vivo Magnetic Resonance Elastography in a Mouse Model of Dopamine Depletion
Klein C., Hain G.E., Braun J., Riek K., Mueller S., Steiner B., Sack I.
Plos One 2014
80. Measurement of in vivo celebral volumetric strain induced by the Valsalva maneuver
Mousavi S.R., Fehlner A, Streitberger J, Braun J, Samani A, Sack I.
Journal of Biomechanics 2014
79. In vivo time-harmonic multifrequency elastography of the human liver
Tzschätzsch H, Ipek-Ugay S, Guo J, Streitberger J, Gentz E, Fischer T, Klaua R, Schultz M, Braun J, Sack I.
Physics in Medicine and Biology 2014
78. Shear-wave Amplitudes Measured with Cardiac MR Elastography for Diagnosis of Diastolic Dysfunction
Elgeti T, Knebel F, Hättasch R, Hamm B, Braun J, Sack I.
Radiology 2014
77. High-resolution mechanical imaging of the human brain by three-dimensional multifrequency magnetic resonance elastography at 7T
Braun J, Guo J, Lützkendorf R, Stadler J, Papazoglou S, Hirsch S, Sack I, Bernarding J.
NeuroImage 2014
2013
76. In Vivo Waveguide Elastography: Effects of Neurodegeneration in Patients with Amyotrophic Lateral Sclerosis
Romano A, Guo J, Proschka T, Meyer T, Hirsch S, Braun J, Sack I and Scheel M.
Magnetic Resonance in Medicine 2013
75. High-resolution mechanical imaging of the kidney
Streitberger KJ, Guo J, Tzschätzsch H, Hirsch S, Fischer T, Braun J, Sack I
Journal of Biomechanics 2013
74. Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson’s disease
Lipp A, Trbojevic R, Paul F, Fehlner A, Hirsch S, Scheel M, Noack C, Braun J, Sack I
NeuroImage 2013
73. Isovolumetric Elasticity Alteration in the Human Heart Detected by In Vivo Time-Harmonic Elastography
Tzschätzsch H, Hättasch R, Knebel F, Klaua R, Schultz M, Jenderka KV, Braun J, Sack I
Ultrasound in Medicine & Biology 2013
72. Non-invasive characterization of intracranial tumors by magnetic resonance elastography
Simon M, J Guo J, Papazoglou S, Scholand-Engler H, Erdmann C, Melchert U, Bonsanto M, Braun J , Petersen D, Sack I, Wuerfel J
New Journal of Physics 2013
71. Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen
Guo J, Hirsch S, Streitberger KJ, Kamphues C, Asbach P, Braun J, Sack I
Fortschr Rönt 2013
70. Towards an Elastographic Atlas of Brain Anatomy
Guo J, Hirsch S, Fehlner A, Papazoglou S, Scheel M, Braun J, Sack I
Plos One 2013 (among the top 10% most cited PLOS ONE articles)
69. Compression-sensitive magnetic resonance elastography
Hirsch S, Beyer F, Guo J, Papazoglou S, Tzschaetzsch H, Braun J, Sack I
Physics in Medicine and Biology 2013
68. Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis—Increased Sensitivity with Optimized Region-of-Interest Delineation
Prokscha T, Guo J, Hirsch S, Braun J, Sack I, Meyer I, Scheel M
Clin Neuroradiol 2013
67. MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density
Freimann F, Müller S, Streitberger KJ, Guo J, Rota S, Ghoria A, Vajkoczya P, Reiter R, Sack I, Braun J
NMR in Biomedicine 2013
66. Structure-sensitive elastography: on the viscoelastic powerlaw behavior of in vivo human tissue in health and disease
Sack I, Joehrens K, Wuerfel J, Braun J
Soft Matter 2013
65. Towards Compression-Sensitive Magnetic Resonance Elastography of the Liver: Sensitivity of Harmonic Volumetric Strain to Portal Hypertension
Hirsch S, Guo J, Reiter R, Schott E, Buening C, Somasundaram R, Braun J, Sack I, Kroencke T
Journal of Magnetic Resonance Imaging 2013
64. MR Elastography of the Liver and the Spleen Using a Piezoelectric Driver, Single-Shot Wave-Field Acquisition, and Multifrequency Dual Parameter Reconstruction
Hirsch S, Guo J, Reiter R, Papazoglou S, Kroencke T, Braun J, Sack I
Magnetic Resonance in Medicine 2013
2012
63. Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis
Riek K, Millward JM, Hamann I, Mueller S, Pfueller C, Paul F, Braun J, Infante-Duarte C, Sack I
NeuroImage 2012
62. In Vivo Measurement of Volumetric Strain in the Human Brain Induced by Arterial Pulsation and Harmonic Waves
Hirsch S, Klatt D, Freimann F, Scheel M, Braun J, Sack I
Magnetic Resonance in Medicine 2012
61. Viscoelasticity-Based Magnetic Resonance Elastography for the Assessment of Liver Fibrosis in Hepatitis C Patients after Liver Transplantation
Kamphues C, Klatt D, Bova R, Yahyazadeh A, Bahra M, Braun J, Klauschen F, Neuhaus P, Sack I, Asbach P
Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (RöFo) 2012
60. Shear Wave Diffusion Observed by Magnetic Resonance Elastography
Papazoglou S, Braun J, Klatt D, Sack I
New Developments in the Visualization and Processing of Tensor Fields
Springer Series: Mathematics and Visualization, Springer
ISBN 978-3-642-27342-1
59. Fractal network dimension and viscoelastic powerlaw behavior: II. An experimental study of structure-mimicking phantoms by magnetic resonance elastography
Guo J, Posnansky O, Hirsch S, Scheel M, Taupitz M, Braun J, Sack I
Physics in Medicine and Biology 2012
58. Fractal network dimension and viscoelastic powerlaw behavior: I. A modeling approach based on a coarse-graining procedure combined with shear oscillatory rheometry
Posnansky O, Guo J, Hirsch S, Papazoglou S, Braun J, Sack I
Physics in Medicine and Biology 2012
57. Measurement of vibration-induced volumetric strain in the human lung
Hirsch S, Posnansky O, Papazoglou S, Elgeti T, Braun J, Sack I
Magnetic Resonance in Medicine 2012
56. Multifrequency inversion in magnetic resonance elastography
Papazoglou S, Hirsch S, Braun J, Sack I
Physics in Medicine and Biology 2012
55. Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus
Freimann FB, Streitberger KJ, Klatt D, Lin K, McLaughlin J, Braun J, Sprung C, Sack I
Neuroradiology 2012
54. Vibration-Synchronized Magnetic Resonance Imaging for the Detection of Myocardial Elasticity Changes
Elgeti T, Tzschätzsch H, Hirsch S, Krefting D, Klatt D, Niendorf T, Braun J, Sack I
Magnetic Resonance in Medicine 2012
53. In Vivo Time Harmonic Elastography of the Human Heart
Tzschätzsch H, Elgeti T, Rettig K, Kargel C, Klaua R, Schultz M, Braun J, Sack I
Ultrasound in Medicine & Biology 2012
52. Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis
Streitberger K-J, Sack I, Krefting D, Pfuller C, Braun J, Friedemann P, Wuerfel J
PLoSOne 2012 (among the top 10% most cited PLOS ONE articles)
51. In Vivo Waveguide Elastography of White Matter Tracts in the Human Brain
Romano A, Scheel M, Hirsch S, Braun J, Sack I
Magnetic Resonance in Medicine 2012
2011
50. Evaluation of tomosynthesis elastography in a breast-mimicking phantom
Engelken FJ, Sack I, Klatt D, Fischer T, Fallenberg EM, Bick U, Diekmann F
European Journal of Radiology 2011
49. The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans
Sack I, Streitberger K-J, Krefting D, Paul F, Braun J
PLoSOne 2011 (among the top 10% most cited PLOS ONE articles)
48. Measurement of the hyperelastic properties of ex vivo brain tissue slices
Kaster T, Sack I, Samani A
Journal of Biomechanics 2011
47. Wide-range dynamic magnetic resonance elastography
Riek K, Klatt D, Nuzha H, Mueller S, Neumann U, Sack I, Braun J
Journal of Biomechanics 2011
46. In vivo viscoelastic properties of the brain in normal pressure hydrocephalus
Streitberger K-J,Wiener E, Hoffmann J, Freimann FB, Klatt D, Braun J, Lin K, McLaughlin J, Sprung C, Klingebiel R, Sack I
NMR in Biomedicine 2011
2010
45. Elasticity-based determination of isovolumetric phases in the human heart
Elgeti T, Beling M, Hamm B, Braun J, Sack I
Journal of Cardiovascular Magnetic Resonance 2010
44. Viscoelasticity-based MR elastography of skeletal muscle
Klatt D, Papazoglou S, Braun J, Sack I
Physics in Medicine and Biology 2010
43. Viscoelasticity-based Staging of Hepatic Fibrosis with Multifrequency MR Elastography
Asbach P, Klatt D, Schlosser B, Biermer M, Muche M, Rieger A, Loddenkemper C, Somasundaram R, Berg T, Hamm B, Braun J, Sack I
Radiology 2010
42. Cardiac Magnetic Resonance Elastography: Toward the Diagnosis of Abnormal Myocardial Relaxation
Elgeti T, Beling M, Hamm B, Braun J, Sack I
Investigative Radiology 2010
41. In Vivo Magnetic Resonance Elastography of Human Brain at 7 T and 1.5 T
Hamhaber U, Klatt D, Papazoglou S, Hollmann M, Stadler J, Sack I, Bernarding J, Braun J
Journal of Magnetic Resonance Imaging 2010
(the cover shows shear wave images acquired in the human brain at 1.5T and 7T magnetic field strengths)
40. Anderson localization of shear waves observed by magnetic resonance imaging
Papazoglou S, Klatt D, Braun J, Sack I
European Physics Letters 2010
39. Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography
Klatt D., Friedrich Chr., Korth Y., Vogt R., Braun J., Sack I.
Biorheology 2010
38. MR-elastography reveals degradation of tissue integrity in multiple sclerosis
Wuerfel J, Paul F, Beierbach B, Wuerfel J, Klatt D, Hamhaber U, Papazoglou S, Zipp F, Martus P, Braun J, Sack I
Neuroimage 2010
2009
37. Cardiac MR Elastography: Comparison with left ventricular pressure measurement
Elgeti T, Laule M, Kaufels N, Schnorr J, Hamm B, Samani A, Braun J, Sack I
Journal of Cardiovascular Magnetic Resonance 2009
36. The impact of aging and gender on brain viscoelasticity
Sack I, Beierbach B, Wuerfel J, Klatt D, Hamhaber U, Papazoglou S, Martus P, Braun J
Neuroimage 2009
35. Scatter-based magnetic resonance elastography
Papazoglou S, Xu C, Hamhaber U, Siebert E, Bohner G, Klingebiel R, Braun J, Sack I
Physics in Medicine and Biology 2009
34. MR Elastography of the Human Heart: Noninvasive Assessment of Myocardial Elasticity Changes by Shear Wave Amplitude Variations
Sack I, Rump J, Elgeti T, Samani A, Braun J
Magnetic Resonance in Medicine 2009
2008
33. Cardiac Magnetic Resonance Elastography: Initial Results
Elgeti T, Rump J, Hamhaber U, Papazoglou S, Hamm B, Braun J, Sack I
Investigative Radiology 2008
32. Assessment of the Solid-Liquid Behavior of the Liver for the Diagnosis of Diffuse Disease Using Magnetic Resonance Elastography
Klatt D, Asbach P, Somasundaram R, Hamm B, Braun J, Sack I
Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (RöFo) 2008
31. Assessment of liver viscoelasticity using multifrequency MR elastography
Asbach P, Klatt D, Hamhaber U, Braun J, Somasundaram R, Hamm B, Sack I
Magnetic Resonance in Medicine 2008
30. Algebraic Helmholtz inversion in planar magnetic resonance elastography
Papazoglou S, Hamhaber U, Braun J, Sack I
Physics in Medicine and Biology 2008
29. Phase preparation in steady-state free precession MR elastography
Rump J, Warmuth C, Braun J, Sack I
Magnetic Resonance Imaging 2008
28. Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography
Sack I, Beierbach B, Hamhaber U, Klatt D, Braun J
NMR in Biomedicine 2008
2007
27. Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity
Klatt D, Hamhaber U, Asbach P, Braun J, Sack I
Physics in Medicine and Biology 2007
26. Fractional encoding of harmonic motions in MR elastography
Rump J, Klatt D, Braun J, Warmuth C, Sack I
Magnetic Resonance in Medicine 2007
25. Plane SH-wave scattering from a nonwelded interface observed by Magnetic Resonance Elastography
Papazoglou, S., Hamhaber, U., Braun, J., Sack, I.
Physics in Medicine and Biology 2007
24. Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain
Hamhaber, U., Sack, I., Papazoglou, S., Rump, J., Klatt, D., Braun, J.
Acta Biomaterialia 2007
2006
23. In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography
Klatt D, Asbach P, Rump J, Papazoglou S, Somasundaram R, Modrow J, Braun J, Sack I
Investigative Radiology 2006
22. Shear wave group velocity inversion in MR elastography of human skeletal muscle
Papazoglou S, Rump J, Braun J, Sack I
Magnetic Resonance in Medicine 2006
21. Alterations of the proton-T2 Time in relaxed skeletal muscle induced by passive extremity flexions
Rump J, Braun J, Papazoglou S, Taupitz M, Sack I
Journal of Magnetic Resonance in Medicine 2006
2005
20. Two-dimensional waveform analysis in MR elastography of skeletal muscles
Papazoglou S, Braun J, Hammhaber U, Sack I
Physics in Medicine and Biology 2005
2004
19. Prospective registration of human head magnetic resonance images for reproducible slice positioning using localizer images
Gedat E, Braun J, Sack I, Bernarding J
Journal of Magnetic Resonance Imaging 2004
18. Observation of non-linear shear wave propagation using Magnetic Resonance Elastography
Sack I, Mcgowan CK, Samani A, Luginbuhl C, Oakden W, Plewes DB
Magnetic Resonance in Medicine 2004
17. An Inductive Method to Measure Mechanical Excitation Spectra for MRI Elastography
Plewes DB, Luginhbuh C, McGowan CK, Sack I
Concepts in Magnetic Resonance 2004
16. Diffusion Weighted Imaging and Magnetic Resonance Elastography of the Sol/Gel Phase Transition in Agarose
Sack, I., Gedat, E., Buntkowsky, G., Bernarding, J., Braun, J.
Journal of Magnetic Resonance 2004
2003
15. An Electromagnetic Actuator for Variable Directioning of Shear Wave Displacement in MR Elastography
Braun J, Braun K, Sack I
Magnetic Resonance in Medicine 2003
2002
14. Analysis of Wave Patterns in MR Elastography at Skeletal Muscle using Coupled Harmonic Oscillator Simulations
Sack I, Bernarding J, Braun J
Magnetic Resonance Imaging 2002
2001
13. Bestimmung lokaler Frequenzen aus Magnetresonanzelastographie Bilddaten
Braun, J., Sack, I., Bernarding, J., Tolxdorff, T.
Informatik, Biometrie und Epidemiologie in Medizin und Biologie 2001
12. Magnetic Resonance Elastography: A Method for the Noninvasive and Spatially Resolved Observation of Phase Transitions in Gels
Sack, I., Buntkowsky, G., Bernarding, J., Braun, J.
Journal of the American Chemical Society 2001
11. Simulation and Analysis of Magnetic Resonance Elastography Wave Images using Coupled Harmonic Oscillators and Gaussian Local Frequency Estimation
Braun, J., Buntkowsky, G., Bernarding, J., Tolxdorff, T., Sack, I.
Magnetic Resonance Imaging 2001
10. Peptide Torsion Angle Measurements: Effects of Nondilute Spin Pairs on Carbon-Observed, Deuterium-Dephased PM5-REDOR
Sack I., Balazs Y. S., Rahimipour S., Vega S.
Journal of Magnetic Resonance 2001
2000
9. Solid-State NMR Study of the SH3 Domain of a–Spectrin – Application of 13C-15N TEDOR and REDOR
Macholl, S., Sack, I., Limbach, H.-H., Pauli, J., Kelly, M., Buntkowsky, G.
Magnetic Resonance in Chemistry 2000
8. Solid-State NMR Determination of Peptide Torsion Angles: Applications of 2H-Dephased REDOR
Sack, I., Balazs, Y. S., Rahimipour, S., Vega, S.
Journal of the American Chemical Society 2000
7. Efficient Carbon-Deuterium REDOR NMR Spectroscopy
Sack, I., Vega, S.
Journal of Magnetic Resonance 2000
6. A 15N-1H Dipolar CSA Solid State NMR Study of Polyglycine (-CO-CD2-15NH-)n Modifications
Sack, I., Macholl, S., Wehrmann, F., Albrecht, J., Limbach, H.-H., Fillaux, F., Baron, M. H., Buntkowsky, G.
Applied Magnetic Resonance 2000
5. Conformational Studies of Polymorphic N-Octyl-D-Gluconamide by 15N Labeled 13C Natural Abundance REDOR Spectroscopy
Sack, I., Macholl, S., Fuhrhop, J. H., Buntkowsky, G.
Physical Chemistry Chemical Physics 2000
1999
4. Deuterium REDOR: Principles and Applications for Distance Measurements
Sack, I., Goldbourt, A., Vega, S., Buntkowsky, G.
Journal of Magnetic Resonance 1999
3. Evidence by 15N CPMAS and 15N-13C REDOR NMR for Reversible Binding of Atmospheric CO2 to Amino Groups in the Solid State
Schimming, V., Hoelger, C., Buntkowsky, G., Sack, I., Fuhrhop, J. H., Rocchetti, S., Limbach, H.-H.
Journal of the American Chemical Society 1999
1997
2. Structure Elucidation of Amide Bonds with Dipolar Chemical Shift NMR Spectroscopy
Buntkowsky, G., Sack, I., Limbach, H.-H., Kling, B., Fuhrhop, J. H.
Journal of Physical Chemistry B 1997
1. 2H NMR Theory of Transition Metal Dihydrides: Coherent and Incoherent Quantum Dynamics
Buntkowsky G, Limbach H-H., Wehrmann F, Sack I, Vieth H M, Morris R H
Journal of Physical Chemistry A 1997