Publications

 

Books

book_cover2

Magnetic Resonance Elastography: Physical Background And Medical Applications
Hirsch S, Braun J, Sack I
Wiley-VCH ISBN-10: 3527340084

Erratum

From the cover:

Magnetic resonance elastography (MRE) is a medical imaging technique that combines magnetic resonance imaging (MRI) with mechanical vibrations to generate
maps of viscoelastic properties of biological tissue. It serves as a non-invasive tool to detect and quantify mechanical changes in tissue structure, which can be
symptoms or causes of various diseases. Clinical and research applications of MRE include staging of liver fi brosis, assessment of tumor stiff ness and investigation of
neurodegenerative diseases. The first part of this book is dedicated to the physical and technological principles underlying MRE, with an introduction to MRI physics,viscoelasticity theory and classical waves, as well as vibration generation, image acquisition and viscoelastic parameter reconstruction.The second part of the book focuses on clinical applications of MRE to various organs. Each section starts with a discussion of the specifi c properties of the organ, followed by an extensive overview of clinical and preclinical studies that have been performed, tabulating reference values from published literature. The book is completed by a chapter discussing technical aspects of elastography methods based on ultrasound.

From the content:

  • NMR and MRI (from Bloch simulations to balanced SSFP-MRE)
  • Motion encoding (from flow compensation to fractional encoding)
  • Theory of elasticity (from generalized Hooke’s law to transverse isotropy)
  • Viscoelasticity (from Kelvin-Voigt to fractal ladders)
  • Elastic waves (from Green’s function to shear wave diffusion)
  • Numerical tools (from phase unwrapping and compact gradient operators to wavelet denoising)
  • Inversion methods (from Helmholtz inversion to waveguide elastography)
  • MRE Hardware (scanners and actuators)
  • Clinical background (the pathological cascade of liver fibrosis, biophysics of cancer, cardiac dysfunction and more)
  • In vivo tissue properties (brain, liver, muscle, heart, spleen, kidney, pancreas, prostate, uterus, intervertebral disc)
  • Ultrasound elastography methods (from ARFI to time harmonic elastography)

 

book_bioqic_cover

Quantification of Biophysical Parameters in Medical Imaging
Sack I, Schäffter T (Editors)
Springer, ISBN-10: 3319659235

From the cover:

This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.

This book reviews current state-of-the-art approaches and technologies in medical imaging. Most of the authors are associated to the Graduiertenkolleg GRK2260 BIOQIC (BIOphysical Quantitative Imaging towards Clinical diagnosis) which is currently funded by the German Research Foundation (DFG).

From the content:

Chapter # Chapter Corresponding author name
1 Preface Ingolf Sack
Part 1 Biological and Physical Fundamentals
2 The fundamentals of transport in living tissues quantified by medical imaging technologies Ingolf Sack
3 Mathematical modeling of blood flow in the cardiovascular system Alfonso Caiazzo
4 Equations of motion for biphasic tissue Sebastian Hirsch
5 Physical Properties of Single Cells and Collective Behavior Hans Kubitschke
6 The extracellular matrix as a target for molecular and biophysical magnetic resonance imaging Matthias Taupitz
Part 2 Medical Imaging Technologies
7 Mathematical Methods in Medical Image Processing Gitta Kutyniok
8 Acceleration strategies for data sampling in MRI Christoph Kolbitsch
9 4D flow MRI Sebastian Schmitter
10 CEST MRI Leif Schröder
11 Innovative PET and SPECT Tracers Ulrich Abram
12 Methods and approaches in ultrasound elastography Heiko Tzschätzsch
13 Photoacoustic imaging: Principles and Applications Jan Laufer
14 Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction Marc Dewey
Part 3 Applications
15 Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology Thoralf Niendorf
16 Extracellular-matrix-specific molecular MR imaging probes for the assessment of aortic aneurysms Marcus Makowski
17 Diffusion based MRI – imaging basics and clinical applications Michael Scheel
18 Quantification of functional heterogeneities in tumors by PET imaging Winfried Brenner
19 Tumor characterization by ultrasound elastography and contrast-enhanced ultrasound Thomas Fischer
20 Sensitivity of tissue shear stiffness to pressure and perfusion in health and disease Jing Guo
21 Radionuclide imaging of cerebral blood flow Ralph Buchert
22 Cardiac perfusion MRI Amedeo Chiribiri
23 Myocardial Perfusion Assessment by 3D and 4D Computed Tomography Marc Dewey

 

 

 


Review Articles

Magnetic Resonance Elastography of the Heart

Elgeti T, Sack I
Curr Cardiovasc Imaging Rep 2014

Characterization of Focal Breast Lesions by Means of Elastography
Fischer T, Sack I, Thomas A
Fortschr Röntgenstr 2013

Magnetresonanzelastographie 2.0: Hochaufgelöste Bildgebung zur Bestimmung von Elastizität, Viskosität und Druck weicher Gewebe

Sack I
Deutsche Medizinische Wochenschrift 2013

Magnetresonanzelastographie der Leber

Sack I, Fischer T, Thomas A, Braun J
Radiologe 2012

Magnetresonanz-Elastographie
Sack I
Deutsche Medizinische Wochenschrift 2008

A selection of our work on Time-harmonic elastography by ultrasound can be found on
https://www.thelastography.com/

 


Peer reviewed original work

2018

Fast tomoelastography of the mouse brain by multifrequency single-shot MR elastography
Bertalan G, Guo J, Tzschätzsch H, Klein C, Barnhill E, Sack I, Braun J
Magnetic Resonance in Medicine 2018

Tomoelastography for the evaluation of pediatric non-alcoholic fatty liver disease
Hudert C, Tzschätzsch H, Rudolph B, Bläker H, Loddenkemper C, Müller H-P, Henning S, Bufler P, Hamm B, Braun J, Holzhütter HG, Wiegand S, Sack I, Guo J
Investigative Radiology 2018

Tomoelastography paired with T2* magnetic resonance imaging detects lupus nephritis with normal renal function
Marticorena Garcia SR, Grossmann M, Bruns A, Dürr M, Tzschätzsch H, Hamm B, Braun J, Sack I, Guo J
Investigative Radiology 2018

Hypercapnia increases brain viscoelasticity
Hetzer S, Dittmann F, Bormann K, Hirsch S, Lipp A, Wang DJJ, Braun J, Sack I
Journal of Cerebral Blood Flow and Metabolism 2018

Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE).
Reiter R, Wetzel M, Hamesch K, Strnad P, Asbach P, Haas M, Siegmund B, Trautwein C, Hamm B, Klatt D, Braun J, Sack I, Tzschätzsch H.
PLoS One 2018

Heterogeneous Multifrequency Direct Inversion (HMDI) for magnetic resonance elastography with application to a clinical brain exam
Barnhill E, Davis PJ, Ariyurek C, Fehlner A, Braun J, Sack I
Medical Image Analysis 2018

Ultrasound time-harmonic elastography: detection of liver fibrosis in extremely obese adolescents with non-alcoholic fatty liver disease
Hudert C, Tzschätzsch H, Guo J, Rudolph B, Bläker H, Loddenkemper C, Luck W, Müller H-P, Baumgart DC, Hamm B, Braun J, Holzhütter HG, Wiegand S, Sack I
Radiology 2018

Full-field-of-view time harmonic elastography of the native kidney
Marticorena Garcia SR, Großmann M, Lang ST, Nguyen Trong M, Schultz M, Guo J, Hamm B, Braun J, Sack I, Tzschätzsch H
Ultrasound in Medicine and Biology 2018

Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer’s disease based on Magnetic resonance imaging
Gerischer LM, Fehlner A, Koebe T, Prehn K, Antonenko D, Grittner U, Braun J, Sack I, Flöel A
Neuroimage: Clinical 2018

2017

Progressive Supranuclear Palsy and idiopathic Parkinson’s disease are associated with local reduction of in-vivo brain viscoelasticity
Lipp A, Skowronek C, Fehlner A, Streitberger K-J, Braun J, Sack I
Europ. Radiol. 2017

Comparison of Ultrasound Shear Wave Elastography with Magnetic Resonance Elastography and Renal Microvascular Flow in the Assessment of Chronic Renal Allograft Dysfunction
Marticorena Garcia SR, Guo J, Dürr M, Denecke T, Hamm B, Sack I, Fischer T
Acta Radiologica 2017

Tomoelastography of the native kidney: Regional variation and physiological effects on in vivo renal stiffness.
Marticorena Garcia SR, Grossmann M, Lang ST, Tzschätzsch H, Dittmann F, Hamm B, Braun J, Guo J, Sack I
Magnetic Resonance in Medicine 2017

Time-harmonic ultrasound elastography of the descending abdominal aorta: initial results.
Schaafs LA, Tzschätzsch H, van der Giet M, Reshetnik A, Steffen IG, Hamm B, Braun J, Sack I, Elgeti T
Ultrasound in Medicine and Biology 2017

Viscoelastic power law parameters of in vivo human brain estimated by MR elastography.
Testu J, McGarry MDJ, Dittmann F, Weaver JB, Paulsen KD, Sack I, Van Houten EEW
J Mech Behav Biomed Mater 2017

Tomoelastography of the prostate using multifrequency MR elastography and externally placed pressurized-air drivers.
Dittmann F, Reiter R, Guo J, Haas M, Asbach P, Fischer T, Braun J, Sack I
Magnetic Resonance in Medicine 2017

MR elastography detection of early viscoelastic response of the murine hippocampus to amyloid β accumulation and neuronal cell loss due to Alzheimer’s disease.
Munder T, Pfeffer A, Schreyer S, Guo J, Braun J, Sack I, Steiner B, Klein C
Jounral of Magnetic Resonance Imaging 2017

A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation.
Braun J, Tzschätzsch H, Körting C, Ariza de Schellenberger A, Jenderka M, Drießle T, Ledwig M, Sack I
Magnetic Resonance in Medicine 2017

Physiological reduction of hepatic venous blood flow by Valsalva maneuver decreases liver stiffness.
Ipek-Ugay S, Tzschätzsch H, Fischer T, Braun J, Sack I
Journal of Ultrasound in Medicine 2017

Perfusion alters stiffness of deep gray matter.
Hetzer S, Birr P, Fehlner A, Hirsch S, Dittmann F, Barnhill E, Braun J, Sack I
Journal of Cerebral Blood Flow and Metabolism 2017

Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans.
Berndt D, Millward JM, Schnorr J, Taupitz M, Stangl V, Paul F, Wagner S, Wuerfel JT, Sack I, Ludwig A, Infante-Duarte C
Nanomedicine 2017

2016

Magnetic Resonance Elastography through Atherosclerosis: A Feasibility Study.
Thomas-Seale LEJ, Kennedy P, Hollis L, Hammer S, Anderson T, Mirsadraee S, Klatt D, Sack I, Pankaj P, Roberts N and Hoskins PR
Journal of Clinical & Experimental Cardiology 2016

Time-harmonic elastography of the liver is sensitive to intrahepatic pressure gradient and liver decompression following transjugular intrahepatic portosystemic shunt (TIPS) implantation.
Tzschätzsch H, Sack I, Marticorena-Garcia SR, Ipek-Ugay S, Braun J, Hamm B, Althoff CE
Ultrasound in Medicine and Biology 2016

Increasing the Spatial Resolution and Sensitivity of Magnetic Resonance Elastography by Correcting for Subject Motion and Susceptibility-induced Image Distortions.
Fehlner A, Hirsch H, Weygandt M, Christophel T, Barnhill E, Kadobianskyi M, Lützkendorf R, Braun J, Bernarding J, Sack I, Hetzer S
Journal of Magnetic Resonance Imaging 2016

Tomoelastography of the abdomen: Tissue mechanical properties of the liver, spleen, kidney and pancreas from single MR elastography scans at different hydration states.
Dittmann F, Tzschätzsch H, Hirsch S, Barnhill E, Braun J, Sack I, Guo J
Magnetic Resonance in Medicine 2016

Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder.
Streitberger K-J, Fehlner A, Pache F, Lacheta A, Papazoglou S, Bellmann-Strobl J, Ruprecht K, Brandt A, Braun J, Sack I, Paul F, Wuerfel J
European Radiology 2016

Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue
Hain EG, Klein C, Munder T, Braun J, Riek K, Mueller S, Sack I, Steiner B
Plos One 2016

Two-dimensional time-harmonic elastography of the human liver and spleen
Tzschätzsch H.,Trong M., Scheuermann T., Ipek-Ugay S., Fischer T., Schultz M., Braun J., Sack I.
Ultrasound in Medicine and Biology 2016

Nonlinear Multiscale Regularisation in MR Elastography: Towards Fine Feature Mapping
Barnhill E, Hollis L, Sack I, Braun J, Hoskins PR, Pankaj P, Brown C, van Beek EJR, Roberts N
Medical Image Analysis 2016

The simulation of magnetic resonance elastography through atherosclerosis.
Thomas-Seale LE, Hollis L, Klatt D, Sack I, Roberts N, Pankaj P, Hoskins PR.
Journal of Biomechanics 2016

Multifrequency Magnetic Resonance Elastography for the Assessment of Renal Allograft Function
Marticorena S., Fischer T., Dürr M., Gültekin E., Braun J., Sack I., Guo J.
Investigative Radiology 2016

Time harmonic elastography reveals sensitivity of liver stiffness to water ingestion
Ipek-Ugay S., Tzschätzsch H., Hudert C., Garcia S.R.M., Fischer T., Braun J., Althoff C. and Sack I.
Ultrasound in Medicine and Biology 2016

Tomoelastography by multifrequency wave number recovery from time-harmonic propagating shear waves
Tzschätzsch H., Guo J., Dittmann F., Hirsch S. , Barnhill E., Jöhrens K., Braun J. and Sack I.
Medical Image Analysis 2016

 

2015

Higher-Resolution MR Elastography Reveals Early Mechanical Signatures of Neuroinflammation in Patients with Clinically Isolated Syndrome
Fehlner A., Behrens J.R., Streitberger K.-J., Papazoglou S., Braun J., Bellmann-Strobl J., Ruprecht K., Paul F., Wuerfel J. and Sack I.
Journal of Magnetic Resonance Imaging 2015

Cover image for Vol. 44 Issue 1

(the cover shows elastograms and parameter difference maps for the disease CIS, which is a very early stage of MS)

In Vivo Wideband Multifrequency MR Elastography of the Human Brain and Liver
Dittmann F., Hirsch S., Tzschätzsch H., Guo J., Braun J. and Sack I.
Magnetic Resonance in Medicine 2015

Cerebral multifrequency MR elastography by remote excitation of intracranial shear waves
Fehlner A., Papazoglou S., McGarry M.D., Paulsen K.D., Guo J., Streitberger K.-J., Hirsch S., Braun J. and Sack I.
NMR in Biomedicine  2015

Time-Resolved Analysis of Left Ventricular Shear Wave Amplitudes in Cardiac Elastography for the Diagnosis of Diastolic Dysfunction
Elgeti T., Steffen I.G., Knebel F., Hättasch R., Hamm B., Braun J. and Sack I.
Investigative Radiology 2016

Three-Parameter Shear Wave Inversion in MR Elastography of Incompressible Transverse Isotropic Media: Application to In Vivo Lower Leg Muscles
Guo J., Hirsch S., Scheel M., Braun J. and Sack I.
Magnetic Resonance in Medicine 2015

Tissue structure and inflammatory processes shape viscoelastic properties of the mouse brain
Millward J.M., Guo J., Dominique Berndt D., Braun J., Sack I. and Infante-Duarte C.
NMR in Biomedicine 2015

In Vivo Abdominal Magnetic Resonance Elastography for the Assessment of Protal Hypertension Before and After Transjugular Intrahepatic Portosystemic Shunt Implantation
Guo J., Büning C., Schott E., Kröncke T., Braun J., Sack I., Althoff C.
Investigative Radiology 2015

US-based Real-time Elastography for the Detection of Fibrotic Gut Tissue in Patients with Stricturing Crohn Disease
Baumgart DC., Müller HP., Grittner U., Metzke D., Fischer A., Guckelberger O., Pascher A., Sack I., Vieth M., Rudolph B.
Radiology 2015

Multifrequency time-harmonic elastography for the measurement of liver viscoelasticity in large tissue windows
Tzschätzsch H., Ipek-Ugay S., Trong M., Guo J., Eggers J., Gentz E., Fischer T.,Schultz M., Braun J., Sack I.
Ultrasound in Medicine and Biology 2015

 

2014

Tabletop Magnetic Resonance Elastography for the Measurement of Viscoelastic Parameters of Small Tissue Samples
Ipek-Ugay S., Drießle T., Ledwig M., Guo J., Hirsch S., Sack I., Braun J.
Journal of Magnetic Resonance 2015

In vivo multifrequency magnetic resonance elastography of the human intervertebral disk
Streitberger J., Diederichs G., Guo J., Fehlner A., Hamm B., Braun J., Sack I.
Magnetic Resonance in Medicine 2014

High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography
Streitberger J., Reiss-Zimmermann M., Freimann F.B., Bayerl S., Guo J., Arlt F., Wuerfel J., Braun J., Hoffmann K.-T., Sack I.
PlosOne 2014

In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix
Jiang X., Asbach P., Streitberger J., Thomas A., Hamm B., Braun J., Sack I., Guo J.
European Radiology 2014

High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography
Reiss-Zimmermann M., Streitberger J., Sack I., Braun J., Arlt F., Fritzsch D., Hoffmann K.-T.
Clin Neuroradiol 2014

Wideband MRE and static mechanical indentation of human liver specimen: Sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis
Reiter R., Freise C., Jöhrens K., Kamphues C., Seehofer D., Stockmann M., Somasundarame R., Asbach P., Braun J., Samani A., Sack I.
Journal of Biomechanics 2014

Enhanced Adult Neurogenesis Increases Brain Stiffness: In Vivo Magnetic Resonance Elastography in a Mouse Model of Dopamine Depletion
Klein C., Hain G.E., Braun J., Riek K., Mueller S., Steiner B., Sack I.
Plos One 2014

Measurement of in vivo celebral volumetric strain induced by the Valsalva maneuver
Mousavi S.R., Fehlner A, Streitberger J, Braun J, Samani A, Sack I.
Journal of Biomechanics 2014

In vivo time-harmonic multifrequency elastography of the human liver
Tzschätzsch H, Ipek-Ugay S, Guo J, Streitberger J, Gentz E, Fischer T, Klaua R, Schultz M, Braun J, Sack I.
Physics in Medicine and Biology 2014

Shear-wave Amplitudes Measured with Cardiac MR Elastography for Diagnosis of Diastolic Dysfunction
Elgeti T, Knebel F, Hättasch R, Hamm B, Braun J, Sack I.
Radiology 2014

High-resolution mechanical imaging of the human brain by three-dimensional multifrequency magnetic resonance elastography at 7T
Braun J, Guo J, Lützkendorf R, Stadler J, Papazoglou S, Hirsch S, Sack I, Bernarding J.
NeuroImage 2014

 

2013

In Vivo Waveguide Elastography: Effects of Neurodegeneration in Patients with Amyotrophic Lateral Sclerosis
Romano A, Guo J, Proschka T, Meyer T, Hirsch S, Braun J, Sack I and Scheel M.
Magnetic Resonance in Medicine 2013

High-resolution mechanical imaging of the kidney

Streitberger KJ, Guo J, Tzschätzsch H, Hirsch S,  Fischer T, Braun J, Sack I
Journal of Biomechanics 2013

Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson’s disease
Lipp A, Trbojevic R, Paul F, Fehlner A, Hirsch S, Scheel M, Noack C, Braun J, Sack I
NeuroImage 2013

Isovolumetric Elasticity Alteration in the Human Heart Detected by In Vivo Time-Harmonic Elastography

Tzschätzsch H, Hättasch R, Knebel F, Klaua R, Schultz M, Jenderka KV, Braun J, Sack I
Ultrasound in Medicine & Biology 2013

Non-invasive characterization of intracranial tumors by magnetic resonance elastography
Simon M, J Guo J, Papazoglou S, Scholand-Engler H, Erdmann C, Melchert U, Bonsanto M, Braun J , Petersen D, Sack I, Wuerfel J
New Journal of Physics 2013

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo J, Hirsch S, Streitberger KJ, Kamphues C, Asbach P, Braun J, Sack I
Fortschr Rönt 2013

Towards an Elastographic Atlas of Brain Anatomy

Guo J, Hirsch S, Fehlner A, Papazoglou S, Scheel M, Braun J, Sack I
Plos One 2013 (among the top 10% most cited PLOS ONE articles)

Compression-sensitive magnetic resonance elastography
Hirsch S, Beyer F, Guo J, Papazoglou S, Tzschaetzsch H, Braun J, Sack I
Physics in Medicine and Biology 2013

Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis—Increased Sensitivity with Optimized Region-of-Interest Delineation

Prokscha T, Guo J, Hirsch S, Braun J, Sack I, Meyer I, Scheel M
Clin Neuroradiol 2013

MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density
Freimann F, Müller S, Streitberger KJ, Guo J, Rota S, Ghoria A, Vajkoczya P, Reiter R, Sack I, Braun J
NMR in Biomedicine 2013

Structure-sensitive elastography: on the viscoelastic powerlaw behavior of in vivo human tissue in health and disease

Sack I, Joehrens K, Wuerfel J, Braun J
Soft Matter 2013

Towards Compression-Sensitive Magnetic Resonance Elastography of the Liver: Sensitivity of Harmonic Volumetric Strain to Portal Hypertension
Hirsch S, Guo J, Reiter R, Schott E, Buening C, Somasundaram R, Braun J, Sack I,  Kroencke T
Journal of Magnetic Resonance Imaging 2013

MR Elastography of the Liver and the Spleen Using a Piezoelectric Driver, Single-Shot Wave-Field Acquisition, and Multifrequency Dual Parameter Reconstruction
Hirsch S, Guo J, Reiter R, Papazoglou S, Kroencke T, Braun J, Sack I
Magnetic Resonance in Medicine 2013

 

2012

Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis

Riek K, Millward JM, Hamann I, Mueller S, Pfueller C, Paul F, Braun J, Infante-Duarte C, Sack I
NeuroImage 2012

In Vivo Measurement of Volumetric Strain in the Human Brain Induced by Arterial Pulsation and Harmonic Waves
Hirsch S, Klatt D, Freimann F, Scheel M, Braun J, Sack I
Magnetic Resonance in Medicine 2012

Viscoelasticity-Based Magnetic Resonance Elastography for the Assessment of Liver Fibrosis in Hepatitis C Patients after Liver Transplantation

Kamphues C, Klatt D, Bova R, Yahyazadeh A, Bahra M, Braun J, Klauschen F, Neuhaus P, Sack I, Asbach P
Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (RöFo) 2012

Shear Wave Diffusion Observed by Magnetic Resonance Elastography
Papazoglou S, Braun J, Klatt D, Sack I
New Developments in the Visualization and Processing of Tensor Fields 
Springer Series: Mathematics and Visualization, Springer 
ISBN 978-3-642-27342-1

Fractal network dimension and viscoelastic powerlaw behavior: II. An experimental study of structure-mimicking phantoms by magnetic resonance elastography
Guo J, Posnansky O, Hirsch S, Scheel M, Taupitz M, Braun J, Sack I
Physics in Medicine and Biology 2012

Fractal network dimension and viscoelastic powerlaw behavior: I. A modeling approach based on a coarse-graining procedure combined with shear oscillatory rheometry

Posnansky O, Guo J, Hirsch S, Papazoglou S, Braun J, Sack I
Physics in Medicine and Biology 2012

Measurement of vibration-induced volumetric strain in the human lung

Hirsch S,  Posnansky O, Papazoglou S, Elgeti T, Braun J, Sack I
Magnetic Resonance in Medicine 2012

Multifrequency inversion in magnetic resonance elastography

Papazoglou S, Hirsch S, Braun J, Sack I
Physics in Medicine and Biology 2012

Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus
Freimann FB, Streitberger KJ, Klatt D, Lin K, McLaughlin J, Braun J, Sprung C, Sack I
Neuroradiology 2012

Vibration-Synchronized Magnetic Resonance Imaging for the Detection of Myocardial Elasticity Changes

Elgeti T, Tzschätzsch H, Hirsch S, Krefting D, Klatt D, Niendorf T, Braun J, Sack I
Magnetic Resonance in Medicine 2012

In Vivo Time Harmonic Elastography of the Human Heart

Tzschätzsch H, Elgeti T, Rettig K, Kargel C, Klaua R, Schultz M, Braun J, Sack I
Ultrasound in Medicine & Biology 2012

Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis

Streitberger K-J, Sack I, Krefting D, Pfuller C, Braun J, Friedemann P, Wuerfel J
PLoSOne 2012 (among the top 10% most cited PLOS ONE articles)

In Vivo Waveguide Elastography of White Matter Tracts in the Human Brain

Romano A, Scheel M, Hirsch S, Braun J, Sack I
Magnetic Resonance in Medicine 2012

 

2011

Evaluation of tomosynthesis elastography in a breast-mimicking phantom
Engelken FJ, Sack I, Klatt D, Fischer T, Fallenberg EM, Bick U, Diekmann F
European Journal of Radiology  2011

The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans
Sack I, Streitberger K-J, Krefting D, Paul F, Braun J
PLoSOne 2011 (among the top 10% most cited PLOS ONE articles)

Measurement of the hyperelastic properties of ex vivo brain tissue slices
Kaster T, Sack I, Samani A
Journal of Biomechanics 2011

Wide-range dynamic magnetic resonance elastography
Riek K, Klatt D, Nuzha H, Mueller S, Neumann U, Sack I, Braun J
Journal of Biomechanics 2011

In vivo viscoelastic properties of the brain in normal pressure hydrocephalus
Streitberger K-J,Wiener E, Hoffmann J, Freimann FB, Klatt D, Braun J, Lin K, McLaughlin J, Sprung C, Klingebiel R, Sack I
NMR in Biomedicine 2011

 

2010

Elasticity-based determination of isovolumetric phases in the human heart
Elgeti T, Beling M, Hamm B, Braun J, Sack I
Journal of Cardiovascular Magnetic Resonance 2010

Viscoelasticity-based MR elastography of skeletal muscle
Klatt D, Papazoglou S, Braun J, Sack I
Physics in Medicine and Biology 2010

Viscoelasticity-based Staging of Hepatic Fibrosis with Multifrequency MR Elastography
Asbach P, Klatt D, Schlosser B, Biermer M, Muche M, Rieger A, Loddenkemper C, Somasundaram R, Berg T, Hamm B, Braun J, Sack I
Radiology 2010

Cardiac Magnetic Resonance Elastography: Toward the Diagnosis of Abnormal Myocardial Relaxation
Elgeti T, Beling M, Hamm B, Braun J, Sack I
Investigative Radiology 2010

In Vivo Magnetic Resonance Elastography of Human Brain at 7 T and 1.5 T
Hamhaber U, Klatt D, Papazoglou S, Hollmann M, Stadler J, Sack I, Bernarding J, Braun J
Journal of Magnetic Resonance Imaging 2010

Journal of Magnetic Resonance Imaging

(the cover shows shear wave images acquired in the human brain at 1.5T and 7T magnetic field strengths)

Anderson localization of shear waves observed by magnetic resonance imaging
Papazoglou S, Klatt D, Braun J, Sack I
European Physics Letters 2010

Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography
Klatt D., Friedrich Chr., Korth Y., Vogt R., Braun J., Sack I.
Biorheology 2010

MR-elastography reveals degradation of tissue integrity in multiple sclerosis
Wuerfel J, Paul F, Beierbach B, Wuerfel J, Klatt D, Hamhaber U, Papazoglou S, Zipp F, Martus P, Braun J, Sack I
Neuroimage 2010

 

2009

Cardiac MR Elastography: Comparison with left ventricular pressure measurement
Elgeti T, Laule M, Kaufels N, Schnorr J, Hamm B, Samani A, Braun J, Sack I
Journal of Cardiovascular Magnetic Resonance 2009

The impact of aging and gender on brain viscoelasticity
Sack I, Beierbach B, Wuerfel J, Klatt D, Hamhaber U, Papazoglou S, Martus P, Braun J
Neuroimage 2009

Scatter-based magnetic resonance elastography
Papazoglou S, Xu C, Hamhaber U, Siebert E, Bohner G, Klingebiel R, Braun J, Sack I
Physics in Medicine and Biology 2009

MR Elastography of the Human Heart: Noninvasive Assessment of Myocardial Elasticity Changes by Shear Wave Amplitude Variations
Sack I, Rump J, Elgeti T, Samani A, Braun J
Magnetic Resonance in Medicine 2009

 

2008

Cardiac Magnetic Resonance Elastography: Initial Results
Elgeti T, Rump J, Hamhaber U, Papazoglou S, Hamm B, Braun J, Sack I
Investigative Radiology 2008

Assessment of the Solid-Liquid Behavior of the Liver for the Diagnosis of Diffuse Disease Using Magnetic Resonance Elastography
Klatt D, Asbach P, Somasundaram R, Hamm B, Braun J, Sack I
Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (RöFo) 2008

Assessment of liver viscoelasticity using multifrequency MR elastography
Asbach P, Klatt D, Hamhaber U, Braun J, Somasundaram R, Hamm B, Sack I
Magnetic Resonance in Medicine 2008

Algebraic Helmholtz inversion in planar magnetic resonance elastography
Papazoglou S, Hamhaber U, Braun J, Sack I
Physics in Medicine and Biology 2008

Phase preparation in steady-state free precession MR elastography
Rump J, Warmuth C, Braun J, Sack I
Magnetic Resonance Imaging 2008

Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography
Sack I, Beierbach B, Hamhaber U, Klatt D, Braun J
NMR in Biomedicine 2008

 

2007

Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity
Klatt D, Hamhaber U, Asbach P, Braun J, Sack I
Physics in Medicine and Biology 2007

Fractional encoding of harmonic motions in MR elastography
Rump J, Klatt D, Braun J, Warmuth C, Sack I
Magnetic Resonance in Medicine 2007

Plane SH-wave scattering from a nonwelded interface observed by Magnetic Resonance Elastography
Papazoglou, S., Hamhaber, U., Braun, J., Sack, I.
Physics in Medicine and Biology 2007

Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain
Hamhaber, U., Sack, I., Papazoglou, S., Rump, J., Klatt, D., Braun, J.
Acta Biomaterialia 2007

 

2006

In Vivo Determination of Hepatic Stiffness Using Steady-State Free Precession Magnetic Resonance Elastography
Klatt D, Asbach P, Rump J, Papazoglou S, Somasundaram R, Modrow J, Braun J, Sack I
Investigative Radiology 2006

Shear wave group velocity inversion in MR elastography of human skeletal muscle
Papazoglou S, Rump J, Braun J, Sack I
Magnetic Resonance in Medicine 2006

Alterations of the proton-T2 Time in relaxed skeletal muscle induced by passive extremity flexions
Rump J, Braun J, Papazoglou S, Taupitz M, Sack I
Journal of Magnetic Resonance in Medicine 2006

 

2005

Two-dimensional waveform analysis in MR elastography of skeletal muscles
Papazoglou S, Braun J, Hammhaber U, Sack I
Physics in Medicine and Biology 2005

 

2004

Prospective registration of human head magnetic resonance images for reproducible slice positioning using localizer images
Gedat E, Braun J, Sack I, Bernarding J
Journal of Magnetic Resonance Imaging 2004

Observation of non-linear shear wave propagation using Magnetic Resonance Elastography
Sack I, Mcgowan CK, Samani A, Luginbuhl C, Oakden W, Plewes DB
Magnetic Resonance in Medicine 2004

An Inductive Method to Measure Mechanical Excitation Spectra for MRI Elastography
Plewes DB, Luginhbuh C, McGowan CK, Sack I
Concepts in Magnetic Resonance 2004

Diffusion Weighted Imaging and Magnetic Resonance Elastography of the Sol/Gel Phase Transition in Agarose
Sack, I., Gedat, E., Buntkowsky, G., Bernarding, J., Braun, J.
Journal of Magnetic Resonance 2004

 

2003

An Electromagnetic Actuator for Variable Directioning of Shear Wave Displacement in MR Elastography
Braun J, Braun K, Sack I
Magnetic Resonance in Medicine 2003

 

2002

Analysis of Wave Patterns in MR Elastography at Skeletal Muscle using Coupled Harmonic Oscillator Simulations
Sack I, Bernarding J, Braun J
Magnetic Resonance Imaging 2002

 

2001

Bestimmung lokaler Frequenzen aus Magnetresonanzelastographie Bilddaten
Braun, J., Sack, I., Bernarding, J., Tolxdorff, T.
Informatik, Biometrie und Epidemiologie in Medizin und Biologie 2001

Magnetic Resonance Elastography: A Method for the Noninvasive and Spatially Resolved Observation of Phase Transitions in Gels
Sack, I., Buntkowsky, G., Bernarding, J., Braun, J.
Journal of the American Chemical Society 2001

Simulation and Analysis of Magnetic Resonance Elastography Wave Images using Coupled Harmonic Oscillators and Gaussian Local Frequency Estimation
Braun, J., Buntkowsky, G., Bernarding, J., Tolxdorff, T., Sack, I.
Magnetic Resonance Imaging 2001

Peptide Torsion Angle Measurements: Effects of Nondilute Spin Pairs on Carbon-Observed, Deuterium-Dephased PM5-REDOR
Sack I., Balazs Y. S., Rahimipour S., Vega S.
Journal of Magnetic Resonance 2001

 

2000

Solid-State NMR Study of the SH3 Domain of a–Spectrin – Application of 13C-15N TEDOR and REDOR
Macholl, S., Sack, I., Limbach, H.-H., Pauli, J., Kelly, M., Buntkowsky, G.
Magnetic Resonance in Chemistry 2000

Solid-State NMR Determination of Peptide Torsion Angles: Applications of 2H-Dephased REDOR
Sack, I., Balazs, Y. S., Rahimipour, S., Vega, S.
Journal of the American Chemical Society 2000

Efficient Carbon-Deuterium REDOR NMR Spectroscopy
Sack, I., Vega, S.
Journal of Magnetic Resonance 2000

A 15N-1H Dipolar CSA Solid State NMR Study of Polyglycine (-CO-CD2-15NH-)n Modifications
Sack, I., Macholl, S., Wehrmann, F., Albrecht, J., Limbach, H.-H., Fillaux, F., Baron, M. H., Buntkowsky, G.
Applied Magnetic Resonance 2000

Conformational Studies of Polymorphic N-Octyl-D-Gluconamide by 15N Labeled 13C Natural Abundance REDOR Spectroscopy
Sack, I., Macholl, S., Fuhrhop, J. H., Buntkowsky, G.
Physical Chemistry Chemical Physics 2000

 

1999

Deuterium REDOR: Principles and Applications for Distance Measurements
Sack, I., Goldbourt, A., Vega, S., Buntkowsky, G.
Journal of Magnetic Resonance 1999

Evidence by 15N CPMAS and 15N-13C REDOR NMR for Reversible Binding of Atmospheric CO2 to Amino Groups in the Solid State
Schimming, V., Hoelger, C., Buntkowsky, G., Sack, I., Fuhrhop, J. H., Rocchetti, S., Limbach, H.-H.
Journal of the American Chemical Society 1999

 

1997

Structure Elucidation of Amide Bonds with Dipolar Chemical Shift NMR Spectroscopy
Buntkowsky, G., Sack, I., Limbach, H.-H., Kling, B., Fuhrhop, J. H.
Journal of Physical Chemistry B 1997

2H NMR Theory of Transition Metal Dihydrides: Coherent and Incoherent Quantum Dynamics
Buntkowsky G, Limbach H-H., Wehrmann F, Sack I, Vieth H M, Morris R H
Journal of Physical Chemistry A 1997